Influential factor and trend of specific IgG antibody titer in coronavirus disease 2019 convalescents / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1172-1175, 2020.
Article
in English
| WPRIM
| ID: wpr-880582
ABSTRACT
OBJECTIVES@#To explore the influential factors and titer trend of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific IgG antibody in convalescent patients with coronavirus disease 2019 (COVID-19), and to provide theoretical basis for the feasibility of clinical treatment of convalescent plasma.@*METHODS@#Colloidal gold immunochromatography assay was used to detect the SARS-CoV-2 specific IgG antibody and its titer in 113 convalescent patients with COVID-19 who were followed up from February 19, 2020 to April 6, 2020. The basic characteristics and treatment factors of patients in the high titer group (antibody titer≥1꞉160, @*RESULTS@#The difference in the clinical type of COVID-19, onset time, first admission C-reactive protein, absolute value of lymphocyte, absolute value of CD19@*CONCLUSIONS@#Male COVID-19 patients might be more likely to produce high titer SARS-CoV-2 specific IgG antibodies than female. The peak level of SARS-CoV-2 specific IgG antibody in convalescent patients is maintained for a short period. Using plasma from convalescent COVID-19 patients for treatment should be within 28 d after discharge.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia, Viral
/
Immunoglobulin G
/
Immunization, Passive
/
Pandemics
/
Betacoronavirus
/
SARS-CoV-2
/
COVID-19
/
Antibodies, Viral
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2020
Type:
Article
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