Efficacy of the combination of endostar with chemotherapy on stage IVb and recurrent metastatic cervical cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1412-1418, 2020.
Article
in English
| WPRIM
| ID: wpr-880600
ABSTRACT
OBJECTIVES@#To observe the efficacy and adverse reactions of the combination of endostar with chemotherapy in the treatment of advanced (IVb) and recurrent metastatic cervical cancer.@*METHODS@#Forty-four patients with recurrent and metastatic cervical cancer, who were admitted to the Second Xiangya Hospital, Central South University from December 2016 to December 2018 were randomly divided into an experimental group and a control group (22 cases in each group). The control group was given gemcitabine plus cisplatin (GP) or docetaxel plus cisplatin (DP) treatment, the experimental group was treated with endostar on the basis of the control group.@*RESULTS@#The objective response rate (ORR) was 42.9% in the experimental group and 22.7% in the control group. There was no significant difference between the 2 groups (@*CONCLUSIONS@#Compared with chemotherapy alone, endostar combined with chemotherapy can prolong the median progression-free survival, with higher ORR and similar adverse reactions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recombinant Proteins
/
Antineoplastic Combined Chemotherapy Protocols
/
Uterine Cervical Neoplasms
/
Cisplatin
/
Endostatins
/
Lung Neoplasms
/
Neoplasm Recurrence, Local
/
Neoplasm Staging
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2020
Type:
Article
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