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Research advances in add-on treatment for negative symptoms and cognitive dysfunction in schizophrenia / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 1457-1463, 2020.
Article in English | WPRIM | ID: wpr-880607
ABSTRACT
Antipsychotic medication is the primary treatment for schizophrenia, which is effective on ameliorating positive symptoms and can reduce the risk of recurrence, but it has limited efficacy for negative symptoms and cognitive dysfunction. The negative symptoms and cognitive dysfunction seriously affects the life quality and social function for the patients with schizophrenia. Currently, there is plenty evidence that antipsychotic drugs combined with adjuvant therapy drugs can effectively improve the negative symptoms and cognitive dysfunction. These drugs include anti-oxidants, nicotinic acetylcholine receptors and neuro-inflammatory drugs (anti-inflammatory drugs, minocycline), which show potential clinical effects.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Antipsychotic Agents / Cognitive Dysfunction / Anti-Inflammatory Agents / Minocycline Type of study: Diagnostic study Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Antipsychotic Agents / Cognitive Dysfunction / Anti-Inflammatory Agents / Minocycline Type of study: Diagnostic study Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2020 Type: Article