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Dual role of interleukin-33 in tumors / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 169-175, 2021.
Article in English | WPRIM | ID: wpr-880639
ABSTRACT
Interleukin-33 (IL-33) is a new member of the IL-1 cytokine family which plays roles in the nucleus as a nuclear factor and is released by damaged or necrotic cells to act as a cytokine. It can be released via damaged or necrotic cells and functions as a cytokine. The released IL-33 activates the downstream NF-κB and MAPKs signaling pathways through the isomers of the specific receptor ST2 and the interleukin-1 receptor accessory protein (IL-1RAcP), resulting in danger signals and the activated multiple immune responses. IL-33 is abnormally expressed in various tumors and involves in tumorigenesis, development, and metastasis. Moreover, IL-33 can play both pro-tumor and anti-tumor roles in the same type of tumor.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cytokines / NF-kappa B / MAP Kinase Signaling System / Interleukin-33 / Neoplasms Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cytokines / NF-kappa B / MAP Kinase Signaling System / Interleukin-33 / Neoplasms Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2021 Type: Article