Dual role of interleukin-33 in tumors / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 169-175, 2021.
Article
in English
| WPRIM
| ID: wpr-880639
ABSTRACT
Interleukin-33 (IL-33) is a new member of the IL-1 cytokine family which plays roles in the nucleus as a nuclear factor and is released by damaged or necrotic cells to act as a cytokine. It can be released via damaged or necrotic cells and functions as a cytokine. The released IL-33 activates the downstream NF-κB and MAPKs signaling pathways through the isomers of the specific receptor ST2 and the interleukin-1 receptor accessory protein (IL-1RAcP), resulting in danger signals and the activated multiple immune responses. IL-33 is abnormally expressed in various tumors and involves in tumorigenesis, development, and metastasis. Moreover, IL-33 can play both pro-tumor and anti-tumor roles in the same type of tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cytokines
/
NF-kappa B
/
MAP Kinase Signaling System
/
Interleukin-33
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Type:
Article
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