Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype: A case report and literature review / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 322-327, 2021.
Article
in English
| WPRIM
| ID: wpr-880662
ABSTRACT
Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic. A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia, who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination. In addition to the typical Ph chromosome, a rare chromosome translocation t(2; 7)(p13; p22) was observed. The detection of monocyte subsets by multi-parameter flow cytometry is a diagnostic marker to distinguish the above 2 diseases. The relationship between fusion genes and mononucleosis is not clear. Tyrosine kinase inhibitors or allogeneic hematopoietic stem cell transplantation can be used in the treatment for this disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Translocation, Genetic
/
Monocytes
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Karyotype
/
Karyotyping
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Type:
Article
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