Progress in study on the association between HLA genetic variation and adverse drug reactions / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 404-413, 2021.
Article
in English
| WPRIM
| ID: wpr-880674
ABSTRACT
The human leukocyte antigen (HLA) molecules encoded within the human major histocompatibility complex are a group of highly conserved cell surface proteins, which are related to antigen recognition. HLA genes display a high degree of genetic polymorphism, which is the basis of individual differences in immunity. Specific HLA genotypes have been highly associated with typical adverse drug reactions. HLA-A*3101 and HLA-B*1502 are associated with carbamazepine-induced severe cutaneous adverse reactions, HLA-B*5701 is related to abacavir-induced drug-induced hypersensitivity syndrome and flucloxacillin/pazopanib-induced drug-induced liver injury, while HLA-B*3501 is a potential biomarker for predicting polygonum multiflorum-induced liver injury. It is not clear how small drug molecules to interact with HLA molecules and T cell receptors (TCR). There are four mechanistic hypotheses, including the hapten/prohapten theory, the pharmacological interaction concept, the altered peptide repertoire model, and the altered TCR repertoire model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Drug-Related Side Effects and Adverse Reactions
/
Genotype
/
HLA Antigens
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Type:
Article
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