RNA methylation and neurovascular unit remodeling / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 536-544, 2021.
Article
in English
| WPRIM
| ID: wpr-880692
ABSTRACT
RNA methylation is of great significance in the regulation of gene expression, among which the more important methylation modifiers are N6-methyladenosine (m6A) and 5-methylcytosine (m5C). The methylation process is mainly regulated by 3 kinds of proteins methyltransferase, demethylase, and reader. m6A, m5C, and their related proteins have high abundance in the brain, and they have important roles in the development of the nervous system and the repair and remodeling of the vascular system. The neurovascular unit (NVU) is a unit of brain structure and function composed of neurons, capillaries, astrocytes, supporting cells, and extracellular matrix. The local microenvironment for NVU has an important role in nerve cell function repair, and the remodeling of NVU is of great significance in the prognosis of various neurological diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA
/
Adenosine
/
5-Methylcytosine
/
Methylation
/
Methyltransferases
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Type:
Article
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