Effect of ozone oil for prevention and treatment of sorafenib-induced hand-foot skin reactions: a randomized controlled trial / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1488-1492, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880773
ABSTRACT
OBJECTIVE@#To compare the effects of medical ozone oil and urea ointment for prevention and treatment of hand-foot skin reaction (HFSR) caused by sorafenib in patients with hepatocellular carcinoma (HCC).@*METHODS@#A total of 99 patients diagnosed with advanced HCC according to National Comprehensive Cancer Network (NCCN) who were scheduled to receive sorafenib treatment for the first time were enrolled in this study between April, 2018 and January, 2020. The patients were randomized into medical ozone oil group (@*RESULTS@#Eight patients were excluded for poor compliance or protocol violations, leaving a total of 91 patients for analysis, including 44 in medical ozone oil group and 47 in urea ointment group. Sixteen (36.4%) of patients in ozone oil group developed HFSR, a rate significantly lower than that in urea ointment group (57.4%; @*CONCLUSIONS@#Medical ozone oil can significantly reduce the incidence and severity of HFSR to improve the quality of life of HCC patients receiving sorafenib treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ozone
/
Phenylurea Compounds
/
Quality of Life
/
Niacinamide
/
Carcinoma, Hepatocellular
/
Hand-Foot Syndrome
/
Sorafenib
/
Liver Neoplasms
/
Antineoplastic Agents
Type of study:
Controlled clinical trial
/
Practice guideline
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2020
Type:
Article
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