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Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway / 南方医科大学学报
Article in Chinese | WPRIM | ID: wpr-880776
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenanthrenes / Rats / Rats, Sprague-Dawley / Diterpenes / Epoxy Compounds / Furans / Glucosides / Kidney / Animals / Anti-Inflammatory Agents Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenanthrenes / Rats / Rats, Sprague-Dawley / Diterpenes / Epoxy Compounds / Furans / Glucosides / Kidney / Animals / Anti-Inflammatory Agents Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article