Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1622-1627, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880783
ABSTRACT
OBJECTIVE@#To investigate the expression of CDC25A in non- small cell lung cancer (NSCLC) tissues and explore its correlation with the clinicpathological features of the patients and the expressions of let-7a1 and let-7c.@*METHODS@#We collected surgical specimens of pathologically confirmed NSCLC tissues and paired adjacent lung tissues from 44 patients and tissues of benign lung lesions from 9 patients. The expressions of CDC25A protein and mRNA in the tissues were detected by immunohistochemistry and fluorescence quantitative RT-PCR, respectively; the expressions of let-7a1 and let-7c mRNA were detected using tail-adding fluorescence quantitative RT-PCR.@*RESULTS@#The positivity rate of CDC25A protein expression was significantly higher in NSCLC tissues than in the adjacent tissues and benign pulmonary lesions (@*CONCLUSIONS@#The expression level of CDC25A is significantly increased in NSCLC with a negative correlation with Let-7c expression, which identifies CDC25A as a possible downstream target gene of Let-7c.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Gene Expression Regulation, Neoplastic
/
Carcinoma, Non-Small-Cell Lung
/
Cdc25 Phosphatases
/
MicroRNAs
/
Lung
/
Lung Neoplasms
/
Lymphatic Metastasis
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2020
Type:
Article
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