Escin alleviates chemotherapy-induced peripheral neuropathic pain by inducing autophagy in the spinal cord of rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1634-1638, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880794
ABSTRACT
OBJECTIVE@#To investigate the effect of escin in relieving chemotherapy-induced peripheral neuropathic pain in rats and explore and the underlying mechanism.@*METHODS@#Eighteen SD rats were randomly divided into 3 groups (@*RESULTS@#The rats in both the escin preconditioning group and escin postconditioning group showed obviously increased thresholds of mechanical allodynia and thermal hyperalgesia as compared with those in the control group (@*CONCLUSIONS@#Escin can alleviate chemotherapy-induced peripheral neuropathic pain in rats possibly by upregulating the expressions of autophagy-related proteins in the spinal cord.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Autophagy
/
Rats, Sprague-Dawley
/
Escin
/
Hyperalgesia
/
Neuralgia
/
Antineoplastic Agents
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2020
Type:
Article
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