IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1550-1556, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880796
ABSTRACT
OBJECTIVE@#To investigate the effect of interleukin-17A (IL-17A) on chemosensitivity of ovarian cancer cells to cisplatin (DDP) and explore the mechanism in light of autophagy regulation.@*METHODS@#Ovarian cancer SKOV3 cells cultured @*RESULTS@#DDP increased the expression of IL-17RA in ovarian cancer SKOV3 cells. Treatment with IL-17A significantly reduced the susceptibility of SKOV3 cells to cisplatin-induced apoptosis (@*CONCLUSIONS@#IL-17A/IL-17RA can decrease chemosensitivity of SKOV3 cells to DDP by upregulating DDP-induced autophagy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Autophagy
/
Cisplatin
/
Apoptosis
/
Drug Resistance, Neoplasm
/
Interleukin-17
/
Cell Line, Tumor
/
Cell Proliferation
/
Receptors, Interleukin-17
/
Antineoplastic Agents
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2020
Type:
Article
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