SBi4211 alleviates gp120-induced central nervous system injury / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1693-1702, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-880820
ABSTRACT
OBJECTIVE@#To explore the protective effect of SBi4211 (heptamidine), an inhibitor of S100B, against central nervous system injury induced by HIV-1 envelope protein gp120.@*METHODS@#In an @*RESULTS@#In the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (@*CONCLUSIONS@#SBi4211 can protect neurons from gp120-induced neurotoxicity possibly by inhibiting the S100B/ RAGE-mediated signaling pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
HIV Envelope Protein gp120
/
Central Nervous System
/
Blotting, Western
/
Astrocytes
/
S100 Calcium Binding Protein beta Subunit
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2020
Type:
Article
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