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SBi4211 alleviates gp120-induced central nervous system injury / 南方医科大学学报
Journal of Southern Medical University ; (12): 1693-1702, 2020.
Article in Chinese | WPRIM | ID: wpr-880820
ABSTRACT
OBJECTIVE@#To explore the protective effect of SBi4211 (heptamidine), an inhibitor of S100B, against central nervous system injury induced by HIV-1 envelope protein gp120.@*METHODS@#In an @*RESULTS@#In the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (@*CONCLUSIONS@#SBi4211 can protect neurons from gp120-induced neurotoxicity possibly by inhibiting the S100B/ RAGE-mediated signaling pathway.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / HIV Envelope Protein gp120 / Central Nervous System / Blotting, Western / Astrocytes / S100 Calcium Binding Protein beta Subunit / Neurons Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / HIV Envelope Protein gp120 / Central Nervous System / Blotting, Western / Astrocytes / S100 Calcium Binding Protein beta Subunit / Neurons Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2020 Type: Article