Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation / 南方医科大学学报
Journal of Southern Medical University
; (12): 31-38, 2021.
Article
in Zh
| WPRIM
| ID: wpr-880824
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the regulatory role of long non-coding RNA Kcnq1ot1 in osteoclast differentiation, osteogenic differentiation and osteoporosis.@*METHODS@#The expression of lnc-Kcnq1ot1, Bglap, Runx2, Alp, Bsp, Nfatc1, Mmp9, Ctsk and Oscar were detected by real-time quantitative PCR (qRT-PCR) in the femoral bones from mouse models of postmenopausal osteoporosis (ovariectomized mice, @*RESULTS@#The expression of lnc-Kcnq1ot1 was significantly upregulated during osteoblast differentiation but downregulated in the bone tissues of osteoporotic mice and during osteoclast differentiation (@*CONCLUSIONS@#Our data demonstrate that lnc-Kcnq1ot1 promotes osteogenic differentiation and alleviates osteoclast differentiation, suggesting the potential of lnc-Kcnq1ot1 as a therapeutic target against osteoporosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Osteoblasts
/
Osteoclasts
/
Osteogenesis
/
Cell Differentiation
/
Cells, Cultured
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2021
Type:
Article