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Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation / 南方医科大学学报
Journal of Southern Medical University ; (12): 31-38, 2021.
Article in Chinese | WPRIM | ID: wpr-880824
ABSTRACT
OBJECTIVE@#To investigate the regulatory role of long non-coding RNA Kcnq1ot1 in osteoclast differentiation, osteogenic differentiation and osteoporosis.@*METHODS@#The expression of lnc-Kcnq1ot1, Bglap, Runx2, Alp, Bsp, Nfatc1, Mmp9, Ctsk and Oscar were detected by real-time quantitative PCR (qRT-PCR) in the femoral bones from mouse models of postmenopausal osteoporosis (ovariectomized mice, @*RESULTS@#The expression of lnc-Kcnq1ot1 was significantly upregulated during osteoblast differentiation but downregulated in the bone tissues of osteoporotic mice and during osteoclast differentiation (@*CONCLUSIONS@#Our data demonstrate that lnc-Kcnq1ot1 promotes osteogenic differentiation and alleviates osteoclast differentiation, suggesting the potential of lnc-Kcnq1ot1 as a therapeutic target against osteoporosis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Osteoclasts / Osteogenesis / Cell Differentiation / Cells, Cultured Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Osteoclasts / Osteogenesis / Cell Differentiation / Cells, Cultured Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2021 Type: Article