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Establishment of a mouse model bearing orthotopic temozolomide-resistant glioma / 南方医科大学学报
Journal of Southern Medical University ; (12): 69-74, 2021.
Article in Chinese | WPRIM | ID: wpr-880829
ABSTRACT
OBJECTIVE@#To establish a mouse model bearing orthotopic temozolomide (TMZ)-resistant glioma that mimics the development of drug resistance in gliomas @*METHODS@#Seventy-eight adult C57BL/6 mice were randomly divided into 6 groups (@*RESULTS@#The mouse models bearing TMZresistant glioma was successfully established. The cells from the high-dose induced group showed a significantly higher colony-forming rate than those from the high-dose control group (@*CONCLUSIONS@#Progressive increase of TMZ doses in mice bearing orthotopic gliomas can effectively induce TMZ resistance of the gliomas.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain Neoplasms / Drug Resistance, Neoplasm / Antineoplastic Agents, Alkylating / Cell Line, Tumor / Disease Models, Animal / Temozolomide / Glioma / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain Neoplasms / Drug Resistance, Neoplasm / Antineoplastic Agents, Alkylating / Cell Line, Tumor / Disease Models, Animal / Temozolomide / Glioma / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Southern Medical University Year: 2021 Type: Article