Effects of bisphenol A on apoptosis of ovarian preantral follicular granulosa cells and ovarian development in mice / 南方医科大学学报
Journal of Southern Medical University
; (12): 93-99, 2021.
Article
in Zh
| WPRIM
| ID: wpr-880833
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of environmental estrogen bisphenol A (BPA) exposure on apoptosis of mouse ovarian preantral follicular granulosa cells and ovarian development and explore the underlying mechanism.@*METHODS@#Mouse ovarian preantral follicular granulosa cells were isolated from female ICR mice at postnatal day (PND) 10 and cultured @*RESULTS@#Compared with the control cells group, the isolated cells exposed to a low concentration of BPA (50 μmol/L) showed a significantly lowered apoptosis rate, increased mitochondrial membrane potential, and enhanced cellular proliferation (@*CONCLUSIONS@#BPA can concentration-dependently regulate the function of ovarian preantral follicular granulosa cells in mice and potentially affects both the pregnant mice and the offspring female mice in light of early ovarian development.
Key words
Full text:
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Index:
WPRIM
Main subject:
Phenols
/
Benzhydryl Compounds
/
Apoptosis
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Ovarian Follicle
/
Granulosa Cells
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Mice, Inbred ICR
Limits:
Animals
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Pregnancy
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2021
Type:
Article