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Effects of bisphenol A on apoptosis of ovarian preantral follicular granulosa cells and ovarian development in mice / 南方医科大学学报
Article in Zh | WPRIM | ID: wpr-880833
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of environmental estrogen bisphenol A (BPA) exposure on apoptosis of mouse ovarian preantral follicular granulosa cells and ovarian development and explore the underlying mechanism.@*METHODS@#Mouse ovarian preantral follicular granulosa cells were isolated from female ICR mice at postnatal day (PND) 10 and cultured @*RESULTS@#Compared with the control cells group, the isolated cells exposed to a low concentration of BPA (50 μmol/L) showed a significantly lowered apoptosis rate, increased mitochondrial membrane potential, and enhanced cellular proliferation (@*CONCLUSIONS@#BPA can concentration-dependently regulate the function of ovarian preantral follicular granulosa cells in mice and potentially affects both the pregnant mice and the offspring female mice in light of early ovarian development.
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Full text: 1 Index: WPRIM Main subject: Phenols / Benzhydryl Compounds / Apoptosis / Ovarian Follicle / Granulosa Cells / Mice, Inbred ICR Limits: Animals / Pregnancy Language: Zh Journal: Journal of Southern Medical University Year: 2021 Type: Article
Full text: 1 Index: WPRIM Main subject: Phenols / Benzhydryl Compounds / Apoptosis / Ovarian Follicle / Granulosa Cells / Mice, Inbred ICR Limits: Animals / Pregnancy Language: Zh Journal: Journal of Southern Medical University Year: 2021 Type: Article