Your browser doesn't support javascript.
loading
USP34 regulates tooth root morphogenesis by stabilizing NFIC / 国际口腔科学杂志·英文版
International Journal of Oral Science ; (4): 7-7, 2021.
Article in English | WPRIM | ID: wpr-880861
ABSTRACT
Tooth root morphogenesis involves two biological processes, root elongation and dentinogenesis, which are guaranteed by downgrowth of Hertwig's epithelial root sheath (HERS) and normal odontoblast differentiation. Ubiquitin-dependent protein degradation has been reported to precisely regulate various physiological processes, while its role in tooth development is still elusive. Here we show ubiquitin-specific protease 34 (USP34) plays a pivotal role in root formation. Deletion of Usp34 in dental mesenchymal cells leads to short root anomaly, characterized by truncated roots and thin root dentin. The USP34-deficient dental pulp cells (DPCs) exhibit decreased odontogenic differentiation with downregulation of nuclear factor I/C (NFIC). Overexpression of NFIC partially restores the impaired odontogenic potential of DPCs. These findings indicate that USP34-dependent deubiquitination is critical for root morphogenesis by stabilizing NFIC.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Tooth Root / Cell Differentiation / NFI Transcription Factors / Morphogenesis / Odontogenesis Language: English Journal: International Journal of Oral Science Year: 2021 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tooth Root / Cell Differentiation / NFI Transcription Factors / Morphogenesis / Odontogenesis Language: English Journal: International Journal of Oral Science Year: 2021 Type: Article