Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Protein & Cell
;
(12): 825-845, 2020.
Article
in English
| WPRIM
| ID: wpr-880875
ABSTRACT
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Movement
/
MAP Kinase Signaling System
/
Mitogen-Activated Protein Kinase 7
/
Focal Adhesion Kinase 1
/
Epithelial-Mesenchymal Transition
/
A549 Cells
/
Lung Neoplasms
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
/
Neoplasm Proteins
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2020
Type:
Article
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