Potentiating CD8

Juanjuan YUAN; Ting CAI; Xiaojun ZHENG; Yangzi REN; Jingwen QI; Xiaofei LU; Huihui CHEN; Huizhen LIN; Zijie CHEN; Mengnan LIU; Shangwen HE; Qijun CHEN; Siyang FENG; Yingjun WU; Zhenhai ZHANG; Yanqing DING; Wei YANG

Potentiating CD8

Juanjuan YUAN; Ting CAI; Xiaojun ZHENG; Yangzi REN; Jingwen QI; Xiaofei LU; Huihui CHEN; Huizhen LIN; Zijie CHEN; Mengnan LIU; Shangwen HE; Qijun CHEN; Siyang FENG; Yingjun WU; Zhenhai ZHANG; Yanqing DING; Wei YANG.

Protein & Cell ; (12): 240-260, 2021.

Article in English | WPRIM | ID: wpr-880931

ABSTRACT

ABSTRACT

Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8

CD8+ T cells; LDLR; PCSK9; TCR; cancer immunotherapy; tumor microenvironment

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Protein & Cell Year: 2021 Type: Article