Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection / 医学前沿
Frontiers of Medicine
;
(4): 746-751, 2020.
Article
in English
| WPRIM
| ID: wpr-880959
ABSTRACT
The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination. Here we examined, using ELISA, the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6-7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection. All samples were positive for IgGs against the S- and N-proteins of SARS-CoV-2. Notably, 14 samples available at 6-7 months post-infection all showed significant neutralizing activities in a pseudovirus assay, with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2. Furthermore, in 10 blood samples from cases at 6-7 months post-infection used for memory T-cell tests, we found that interferon γ-producing CD4
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Viral Proteins
/
Immunoglobulin G
/
T-Lymphocytes
/
Cohort Studies
/
Antibodies, Neutralizing
/
Adaptive Immunity
/
SARS-CoV-2
/
COVID-19
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Frontiers of Medicine
Year:
2020
Type:
Article
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