Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 952-956, 2020.
Article
in English
| WPRIM
| ID: wpr-881041
ABSTRACT
Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins (1-9) were identified from a recombinant mutant strain S35-LAL by overexpressed the large-ATP-binding regulator of the LuxR family (LAL) gene aas1 in Streptomyces sp. S35. All the compounds showed no anti-microbial, anti-T3SS and cytotoxic activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptomyces
/
Biological Products
/
Multigene Family
/
Organisms, Genetically Modified
/
Lactams, Macrocyclic
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2020
Type:
Article
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