Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment
Acta Pharmaceutica Sinica B
;
(6): 609-620, 2021.
Article
in English
| WPRIM
| ID: wpr-881159
ABSTRACT
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance. The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6 (IL-6) and interferon-
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Acta Pharmaceutica Sinica B
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS