Design, synthesis and biological evaluation of pyrazolo3,4-

Xiaowei WU; Mengdi DAI; Rongrong CUI; Yulan WANG; Chunpu LI; Xia PENG; Jihui ZHAO; Bao WANG; Yang DAI; Dan FENG; Tianbiao YANG; Hualiang JIANG; Meiyu GENG; Jing AI; Mingyue ZHENG; Hong LIU

Xiaowei WU; Mengdi DAI; Rongrong CUI; Yulan WANG; Chunpu LI; Xia PENG; Jihui ZHAO; Bao WANG; Yang DAI; Dan FENG; Tianbiao YANG; Hualiang JIANG; Meiyu GENG; Jing AI; Mingyue ZHENG; Hong LIU.

Acta Pharmaceutica Sinica B ; (6): 781-794, 2021.

Article in En | WPRIM | ID: wpr-881169

Responsible library: WPRO

ABSTRACT

ABSTRACT

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-

Key words

Antitumor efficacy; BTK, brutons tyrosine kinase; CADD, computer-aided drug design; Covalent FGFR inhibitors; EGFR, epidermal growth factor receptor

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Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: 1 Index: WPRIM Language: En Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article