Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study

Wenhao WANG; Zhengwei HUANG; Yanbei LI; Wenhua WANG; Jiayu SHI; Fangqin FU; Ying HUANG; Xin PAN; Chuanbin WU

Wenhao WANG; Zhengwei HUANG; Yanbei LI; Wenhua WANG; Jiayu SHI; Fangqin FU; Ying HUANG; Xin PAN; Chuanbin WU.

Acta Pharmaceutica Sinica B ; (6): 1030-1046, 2021.

Article in English | WPRIM | ID: wpr-881183

ABSTRACT

ABSTRACT

When nanoparticles were introduced into the biological media, the protein corona would be formed, which endowed the nanoparticles with new bio-identities. Thus, controlling protein corona formation is critical to

BSA corona-Caused aggregation; Cell uptake; Conformational structure; Medium pH; Nanoparticle-protein interaction; Protein corona; Size effect; Solid lipid nanoparticles

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article