Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

Shaoyong LU; Yingyi CHEN; Jiacheng WEI; Mingzhu ZHAO; Duan NI; Xinheng HE; Jian ZHANG

Shaoyong LU; Yingyi CHEN; Jiacheng WEI; Mingzhu ZHAO; Duan NI; Xinheng HE; Jian ZHANG.

Acta Pharmaceutica Sinica B ; (6): 1355-1361, 2021.

Article in English | WPRIM | ID: wpr-881204

ABSTRACT

ABSTRACT

The recent discovery of activator compounds binding to an allosteric site on the NAD

ADPR, ADP-ribose; Allosteric driver; Allosteric mechanisms; Allosteric sites; Drug design

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Type: Article