Research progress on determination of intracellular concentration of immunosuppressant / 器官移植
Organ Transplantation
;
(6): 489-2021.
Article
in Chinese
| WPRIM
| ID: wpr-881536
ABSTRACT
Currently, extracellular concentration measurement is the major approach of therapeutic drug monitoring (TDM) of clinical immunosuppressant in organ transplantation. Its correlation with the efficacy of immunosuppressant remains elusive. With widespread application of liquid chromatography, the detection technology of intracellular concentration of immunosuppressant is gradually mature. Theoretically, it may more accurately reflect the efficacy of immunosuppressant due to that the level of drug exposure in target cells can be directly measured. In this article, the history and present situation of the determination of intracellular concentration of immunosuppressant were summarized, and the association between the determination methods of intracellular concentration of immunosuppressant and drug efficacy was emphatically analyzed. Detection of intracellular concentration of immunosuppressant possesses better application value in clinical practice, which is worthy of promotion in clinical settings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Organ Transplantation
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS