Clinical analysis of occupational acute toxic nephropathy by dimethyl oxalate / 中国职业医学
China Occupational Medicine
;
(6): 489-491, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-881728
ABSTRACT
OBJECTIVE:
To investigate the clinical features and treatment methods of occupational acute dimethyl oxalate(DMO) toxic nephropathy.METHODS:
Occupational history,clinical manifestation,laboratory examination and therapy of one occupational DMO poisoning case were retrospectively analyzed.RESULTS:
The patient was exposed to a large amount of DMO in a short time,with the main symptoms of dizziness,fatigue,nausea,vomiting,bloating,and oliguria.Glomerular filtration reduced after 48 hours of disease onset,serum urea nitrogen was 21. 9 mmol/L and serum creatinine was 788 μmol/L. Renal biopsy showed glomerular mesangial proliferative lesions,tubulointerstitial lesions,small arterial intima thickening and hyaline degeneration. Early treatment,including hemodialysis,hemoperfusion,hormone shock therapy,protection of myocardium,renal function,and improvement of circulation achieved a good clinical prognosis.CONCLUSION:
The main clinical manifestation of acute DMO poisoning is acute kidney injury. Blood purification treatment and hormone shock therapy should be used early.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Occupational Medicine
Year:
2018
Type:
Article
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