Effect of Hyperbilirubinemia on the Brainstem Auditory Evoked Response in Newborn Piglets
Journal of the Korean Society of Neonatology
;
: 248-253, 2003.
Article
in Korean
| WPRIM
| ID: wpr-88196
ABSTRACT
PURPOSE:
We sought to know the effect of hyperbilirubinemia on brainstem auditory evoked response in newborn piglets.METHODS:
To achieve the concentration of bilirubin above 20 mg/dL, we injected a bolus of 50 mg/kg of bilirubin intravenously over 30 minutes, followed by 30-40 mg/kg/ hr of bilirubin continuous intravenous infusion to 10 newborn piglets. Brainstem auditory evoked responses were obtained from these piglets at baseline, 1 hour, 2 hours, 3 hours and 4 hours after the exposure to hyperbilirubinemia.RESULTS:
The mean amplitude of wave V was 0.33+/-0.03 microV at baseline, 0.32+/-0.04 microV at 1 hour, 0.33+/-0.05 microV at 2 hours, 0.23+/-0.04 microV at 3 hours and 0.26+/-0.05 microV at 4 hours of experiment and began to decrease after 3 hours of the exposure to hyperbilirubinemia. The latency of wave III was 4.06+/-0.08 ms at baseline, 3.95+/-0.09 ms at 1 hour, 4.05+/-0.10 ms at 2 hours, 4.05+/-0.09 ms at 3 hours, 4.12+/-0.11 ms at 4 hours of experiment and began to increase after 1 hour of the exposure to hyperbilirubinemia.CONCLUSION:
Hyperbilirubinemia decreased the amplitude of wave V and increased the latency of wave III of brainstem auditory evoked responses in newborn piglets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bilirubin
/
Infusions, Intravenous
/
Brain Stem
/
Evoked Potentials, Auditory
/
Hyperbilirubinemia
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Journal of the Korean Society of Neonatology
Year:
2003
Type:
Article
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