Bayesian network-based analysis on the influence of interaction between genes and occupational stress on hypertension in oil workers / 中国职业医学
China Occupational Medicine
;
(6): 39-45, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-881967
ABSTRACT
OBJECTIVE:
To analyze the effect of gene-gene and gene-occupational stress interaction on hypertension in oil workers by Bayesian network(BN) analysis.METHODS:
A total of 1 233 oil workers from Xinjiang Karamay Oilfield Company were selected as research subjects by the typical sampling method. The blood pressure was measured. The polymerase chain reaction-restriction fragment length polymorphism was used to evaluate the single nucleotide polymorphism(SNP) in α-adductin(ADD1) and β_2-adrenal receptor(β_2-AR) genes. The Effort-Reward Imbalance(ERI) Questionnaire was used to evaluate the ERI model occupational stress of oil workers. BN was used to analyze gene-gene and gene-occupational stress interactions.RESULTS:
The detection rate of hypertension and ERI model occupational stress of these oil workers were 25.5%(315/1 233) and 47.4%(585/1 233) respectively. The AA, AG, and GG genotype and the frequency distribution of allele A and G at ADD1 rs17833172 were statistically different in these two groups(all P<0.05). There was no statistical significance in genotypes of GG, GT and TT at Gly460Trp rs4961(P>0.05); but the difference of the frequency of G and T alleles was statistically significant(P<0.05). There was no statistical significance in genotype distribution of AA, AG and GG, and frequency distribution of A and G in β_2-AR-1023 G/A rs2053044 and+252 G/A rs1042717(all P>0.05). After controlling the confounding factors including gender, education level, marital status, smoking, alcohol drinking and body mass index, the occupational stress group had a higher risk of hypertension than the no-occupational stress group(P<0.05, the odds ratio was 1.33, the 95% confidence interval was 1.01-1.74). The directed acyclic graph constructed by BN showed that the rs17833172 and Gly460Trp rs4961 sites of the ADD1 gene was directly associated with hypertension, and the β_2-AR+252 G/A rs1042717 site was indirectly associated with hypertension because of the ADD1 rs17833172 and Gly460Trp rs4961 sites. The interaction between occupational stress and ADD1 and β_2-AR was not associated with hypertension.CONCLUSION:
The incidence of hypertension in oil field workers is correlated to occupational stress, and ADD1 gene rs17833172 and Gly460Trp rs4961 polymorphism. The gene-gene interaction between β_2-AR+252 G/A rs1042717 locus and ADD1 Gly460Trp rs4961 and rs17833172 locus is associated with hypertension, while the interaction between the four loci of ADD1 and β_2-AR and occupational stress has no effect on hypertension in the oil workers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Occupational Medicine
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS