Research progress on the effect of TSG-6 secreted from mesenchymal stem cells in repairing tissue injury / 中国职业医学
China Occupational Medicine
;
(6): 93-97, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-881978
ABSTRACT
Mesenchymal stem cells(MSCs) have functions such as immune regulation and tissue damage repair, but the specific mechanisms of their effects need to be further studied. Paracrine effect is an important mechanism for MSCs to achieve immune regulation, relieve inflammation and repair tissue damage. Tumor necrosis factor α(TNF-α) stimulated protein 6(TSG-6) is one of the paracrine factors of MSCs, which has significant inflammation inhibitory capability and tissue repair ability. It is an important cytokine of MSCs to exert their anti-inflammatory and anti-fibrotic effects. The MSCs can repair tissue damage in kidney, peritonea, skin, liver, lung, cornea, nervous system, and colon by secreting TSG-6. This powerful repair ability could be attributed to the ability of TSG-6 to inhibit the secretion of pro-inflammatory cytokines and pro-fibrogenic factors, such as TNF-α, interleukin(IL)-6, IL-1β and transforming growth factor-β1, thereby reducing the inflammatory response and fibrosis of the body.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Occupational Medicine
Year:
2021
Type:
Article
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