Progress of ferroptosis and its role in kidney disease / 国际儿科学杂志

ABSTRACT

Ferroptosis is a newly discovered regulatory mode of cell death, which is caused by glutathione peroxidase 4 deficiency, abnormal iron metabolism and lipid peroxidation.At present, it is considered that iron metabolism and active oxygen metabolism are the central link of ferroptosis.Ferroptosis involves a variety of physiological and pathological processes, including cancer cell death, neurotoxicity, ischemia-reperfusion injury, and T-cell immunity.Studies have shown that ferroptosis characteristics such as iron overload and lipid peroxidation may occur in different degrees during the development of a variety of nephropathy.Ferroptosis can affect the progression of renal disease by regulating the level of intracellular iron ions and lipid peroxidation.Therefore, effective regulation of ferroptosis is expected to be an important strategy in the treatment of renal diseases.In this paper, the regulation mechanism of ferroptosis and its research progress in kidney disease are reviewed to provide new theories and ideas for the treatment of renal disease.