Research progress of platelets in sepsis / 中国小儿急救医学

ABSTRACT

Sepsis is an inflammatory response syndrome caused by systemic immune disorders caused by infection.Platelets play an important role in the development of sepsis.Platelets can react with pathogenic microorganisms through adhesion, aggregation, activation, threshing, and have achieved the role of protecting in the body.At the same time, during sepsis, platelets can also interact with immune cells such as neutrophils and participate in formation of microthrombi and inflammation.Therefore, platelets have an antimicrobial effect and cooperate with other innate immune cells to form a complex intravascular immune defense system to prevent the spread of bacteria.However, if the internal immune function mediated by it is dysregulated, the host cells and tissues may be seriously collaterally damaged, resulting in sepsis-related organ dysfunction.This article reviewed the research progress of platelet immune mechanism and organ dysfunction in sepsis.