Research progress of Wnt signaling pathway and its interaction with other signaling pathways in osteoarthropathy / 中华地方病学杂志

ABSTRACT

Osteoarthropathy is a progressive disease that causes the degeneration of articular cartilage due to biological and mechanical factors. The destruction of the articular cartilage matrix and the reduction of articular cartilage cells are the core part of its pathological development, and subchondral bone, synovial membrane and joint capsule are also damaged. The Wnt signaling pathway not only plays an essential role in human development and the maintenance of adult tissue homeostasis, but also functions in the joint formation, articular cartilage development, and the occurrence and development of osteoarthropathy. It has become increasingly popular in joint pathology. In this paper, authors attempted to review the research progress of Wnt signaling pathway and its interaction with other signaling pathways in osteoarthropathy.