Curative effect of biopolysaccharide colloidal solution on the prevention of intestinal adhesion after abdominal surgery / 中国基层医药

ABSTRACT

Objective:To investigate the clinical efficacy and safety of biopolysaccharide colloidal solution (Shutaishu) in the prevention of intestinal adhesion after abdominal surgery.Methods:A total of 100 patients scheduled to undergo abdominal surgery in Quzhou Municipal Hospital of Traditional Chinese Medicine from February to October in 2019 were included in this study. They were randomly divided into an observation group and a control group, with 50 patients in each group. Before closing the abdomen after surgery, abdominal cavity and wound were flashed with Shutaishu and 0.9% sodium chloride injection in the observation and control groups, respectively. The recovery of gastrointestinal function, intestinal adhesion, abdominal pain and the incidence of complications were compared between the observation and control groups.Results:The time to first regular bowel sound [(28.81 ± 5.56) h], time to first passage of flatus [(36.34 ± 6.24) h], time to first defecation [(41.65 ± 8.77) h], time taken for walking [(3.78 ± 0.64) d] in the observation group were significantly shorter than those in the control group [(32.75 ± 5.15) h, (41.51 ± 6.84) h, (48.05 ± 9.81) h, (4.27 ± 0.69) d, t = 3.68, 3.95, 3.89, 3.68, all P < 0.001]. At 5 and 30 days after surgery, the incidence of intestinal adhesion in the observation group [10.0% (5/50), 12.0% (6/50)] was significantly lower than that in the control group [26.0% (13/50), 30.0% (15/50), χ2 = 4.34, 4.88, both P < 0.05]. The total incidence of postoperative complications in the observation group was significantly lower than that in the control group [26.0% (13/50) vs. 54.0% (27/50), χ2 = 8.17, P < 0.05]. With time, visual analogue scale score was significantly decreased in both groups ( t = 3.51, 6.18, both P < 0.05). At 1, 3 and 5 days after surgery, visual analogue scale score in the observation group was significantly lower than that in the control group ( t = 4.07, 4.95 and 8.02, all P < 0.05). Conclusion:Biopolysaccharide colloidal solution is of high clinical value in the prevention of intestinal adhesion after abdominal surgery because it can promote the recovery of gastrointestinal function and early functional exercise, and has no obvious adverse reactions and complications.