Advancement in the relationship between DNA methylation and sepsis / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 500-505, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-883916
ABSTRACT
Epigenetic modification includes DNA methylation, histone modification, non-coding RNA, etc., and is crucial in determining gene expression. A growing number of recent studies have shown that epigenetic regulation may play a central role in the pathogenesis of sepsis. Due to its explicit mechanism and relatively mature technic, DNA methylation has received extensive attention in sepsis-related researches. By examining recent studies on septic DNA methylation mechanism, this review elucidates the key role in sepsis occurrence and progression that DNA methylation plays from etiology, immunology and other aspects, as well as its application potential in the diagnosis, prognosis and treatment of sepsis before pointing out the direction for further research.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Critical Care Medicine
Year:
2021
Type:
Article
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