Advances in the mechanism of microRNAs regulating acute lung injury in sepsis / 中国综合临床

ABSTRACT

Sepsis is a systemic inflammatory disease caused by infection that affects the lungs and can develop into acute lung injury or acute respiratory distress syndrome.Acute lung injury caused by sepsis is one of the common critical diseases in intensive care unit, which is often manifested as intractable hypoxemia, diffuse double pneumonia infiltration, pulmonary edema, etc.Its pathogenesis is complex, and there is no specific treatment method at present.MicroRNAs are non-coding gene regulators involved in the regulation of various physiological and pathological processes of the body, including sepsis acute lung injury.This paper briefly summarized the pathophysiological mechanism of acute lung injury in sepsis, summarized the regulatory mechanism of miRNAs on alveolar macrophages, epithelial cells and endothelial cells during the pathogenesis of ALI, and finally comprehensively expounded the current situation and future direction of miRNAs in the treatment of acute lung injury in sepsis.