The Effect of COX-2 Inhibitor on the Expression of MMP-13 during Early Fracture Healing Phase in Rats
Journal of the Korean Fracture Society
;
: 45-50, 2009.
Article
in English
| WPRIM
| ID: wpr-88456
ABSTRACT
PURPOSE:
This study investigated the effect of COX-2 inhibitor on the expression of MMP-13 in the healing process of fracture. MATERIAL ANDMETHODS:
Adult Sprague-Dawley rats were divided into two groups of twenty five rats each. Unilateral femoral shaft fractures were created artificially under displacement in all two groups. COX-2 inhibitor was only given to the experimental group from the postoperative day 1. At 2 weeks after fracture the rats were sacrificed and the callus from each group was used for histologic examination and real time RT-PCR for MMP-13 expression.RESULTS:
Histologically, proliferation of osteoblasts and formation of osteoid was less abundant in the experimental group. In real time RT-PCR, the mean expression of MMP-13 is 2.84+/-2.50 in the control group compared with 1.16+/-1.05 in the experimental group.CONCLUSION:
In the early stage of fracture healing, COX-2 inhibitor suppress the expression of MMP-13.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Bony Callus
/
Rats, Sprague-Dawley
/
Fracture Healing
/
Displacement, Psychological
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of the Korean Fracture Society
Year:
2009
Type:
Article
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