Research progress of radionuclide labeled fibroblast activation protein targeted molecular probes / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging
;
(6): 180-184, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-884792
ABSTRACT
Fibroblast activation protein (FAP) is a marker protein of cancer-associated fibroblasts(CAFs). It is highly expressed in more than 90% of epithelial cancers and hardly expressed in normal tissues. Therefore, FAP is a very promising target. Radionuclide labeled FAP targeted molecular probes can be used for PET or SPECT imaging. In particular, 68Ga-FAP inhibitors (FAPIs) PET/CT has shown good prospects in the clinic, providing a new idea for early diagnosis, accurate staging and radionuclide treatment of tumors. In addition, FAP is also highly expressed in certain non-tumor diseases, especially those related to fibrosis. In this article, the research progress of radionuclide-labeled FAP targeted molecular probes is reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Screening study
Language:
Chinese
Journal:
Chinese Journal of Nuclear Medicine and Molecular Imaging
Year:
2021
Type:
Article
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