The pathogenesis of frailty syndrome / 中华老年医学杂志

ABSTRACT

Frailty is a geriatric syndrome characterized by increased vulnerability to degenerative changes and various chronic diseases, and is associated with a series of negative clinical events.The pathogenesis of frailty is unclear, and population cohort and observational research has made progress in understanding the biological characteristics of frailty, especially about the hypothalamic-pituitary-adrenal axis and neuroendocrine dysfunction, chronic inflammation and immune system ageing, cell senescence, energy metabolism dysfunction, social environmental psychological factors and chronic diseases, among others.This article reviews the pathogenesis of frailty in the elderly.