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Relationship between preoperative breast specific gamma imaging tumor/normal take-up ratio and the prognosis of breast cancer / 中华普通外科杂志
Chinese Journal of General Surgery ; (12): 191-195, 2021.
Article in Chinese | WPRIM | ID: wpr-885274
ABSTRACT

Objective:

To investigate the relationship between T/N take-up value and the clinic feature of breast cancer, and explore the predictive ability of T/N take-up value for breast cancer prognosis.

Methods:

Breast cancer patients treated at Zhongshan Hospital, Fudan University and undergoing BSGI examination before surgery from Jan 2014 to Nov 2018 were collected. The relationship between T/N take-up value and the clinical features of breast cancer and DFS was analyzed.

Results:

A total of 419 breast cancer patients were collected. The median follow-up time after operation was 34 months. At the end of the follow-up, 43 cases relapsed and 376 cases did not. The average T/N values of CC position and MLO position before surgery were 2.74 and 2.58. The T/N value of CC is related to tumor stage (χ 2=22.077, P<0.05), lymph node metastasis ( Z=2.138, P<0.05) and degree of invasion ( Z=3.371, P<0.05). The T/N value of MLO is related to tumor stage (χ 2=23.091, P<0.05), lymph node metastasis ( Z=2.531, P<0.05) and degree of invasion ( Z=2.99, P<0.05). The best cut-off values of CC position and MLO position calculated by ROC curve are 2.59 and 2.97. Univariate analysis showed that tumor staging ( HR 2.039, 95% CI 1.404-2.962, P=0.001), T/N value at CC position ( HR 4.349, 95% CI 2.141-8.883, P<0.001) and T/N value at MLO position ( HR 2.767, 95% CI 1.520-5.039, P<0.001) is an independent risk factor for the prognosis of breast cancer. Multivariate COX regression analysis showed that tumor stage ( HR 1.959, 95% CI 1.302-2.946, P=0.001) and T/N value at MLO position ( HR 3.498, 95% CI 1.531-7.992, P=0.003) are independent risk factor of breast cancer prognosis.

Conclusion:

The BSGI T/N value has a certain correlation with breast cancer DFS.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of General Surgery Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of General Surgery Year: 2021 Type: Article