Pay attention to secondary neurodegeneration in remote regions after stroke and cognitive impairment / 中华神经科杂志

ABSTRACT

Post-stroke cognitive impairment (PSCI) seriously affects neurological recovery and quality of life of patients. Its mechanism, clinical evaluation, intervention have become research hotspot at home and abroad. Many studies have confirmed that secondary neurodegeneration in remote cognitive-related brain not affected by ischemia after stroke is one of the mechanisms of PSCI. It has been found in rodents that β-amyloid deposition and neuron loss in distant cognitive-related brain regions are involved in the occurrence of cognitive dysfunction and reducing these secondary damages can improve cognitive function. Experiments involving non-human primates have found neuronal loss but no β-amyloid deposition in distant brain regions after stroke. Clinical studies have found associations between secondary neurodegeneration in remote regions and cognitive function by using neuroimaging techniques, but the relationship between PSCI and β-amyloid deposition is not clear now. Due to its late occurrence time and wider therapeutic time window, its intervention treatment is expected to alleviate cognitive impairment, which has great clinical significance.