Effects of Antiepileptic Drugs on the Carotid Artery Intima-Media Thickness in Epileptic Patients
Journal of Clinical Neurology
;
: 371-379, 2017.
Article
in English
| WPRIM
| ID: wpr-88554
ABSTRACT
BACKGROUND AND PURPOSE:
It has been reported that taking antiepileptic drugs (AEDs) may increase the risk of atherosclerosis. We performed a meta-analysis to evaluate the carotid artery intima-media thickness (CA-IMT) as a surrogate factor for atherosclerosis in epileptic patients.METHODS:
We searched NCBI (PubMed), ISI Web of Knowledge, EMBASE, and the Cochrane Library databases for studies of the association between AEDs and CA-IMT in epileptic patients. A random-effects meta-analysis was used to pool results across studies.RESULTS:
Fifteen studies involving 1,775 epileptic patients were included in the analysis. The overall CA-IMT was significantly larger among users of AEDs [mean difference (MD)=0.09 mm, 95% confidence interval (CI)=0.06–0.12 mm). When stratified by age, the MD was similar in adult patients (MD=0.09 mm, 95% CI=0.06–0.13 mm), but no significant difference was observed in children (MD=0.03 mm, 95% CI=0.00–0.07 mm). Regarding specific AEDs, monotherapy with carbamazepine (CBZ) or valproic acid (VPA) was associated with a larger CA-IMT, while phenytoin monotherapy was not and the result for lamotrigine was inconclusive.CONCLUSIONS:
This study suggests that using AEDs is associated with the CA-IMT in patients with epilepsy, particularly for adult patients. In particular, CBZ and VPA may be related to a significant increase in CA-IMT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenytoin
/
Carbamazepine
/
Carotid Arteries
/
Valproic Acid
/
Epilepsy
/
Atherosclerosis
/
Anticonvulsants
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2017
Type:
Article
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