Progress of cell death induced by Neddylation modification pathway inhibitor MLN4924 / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 393-396, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-886068
ABSTRACT
Protein ubiquitin-like modification of Neddylation is an important post-translational modification mode of protein to widely regulate cell cycle, growth, development and other biological processes. Recent studies have found that MLN4924, small molecule inhibitor of Neddylation modification, has a significant anti-tumor effect, which can inhibit the tumor growth by inducing cell cycle arrest, senescence and apoptosis, and inhibiting tumor angiogenesis. This paper reviews the related mechanism research of cell programmed death induced by Neddylation modification pathway inhibitor MLN4924.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Cancer Research and Clinic
Year:
2021
Type:
Article
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