The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis / 药学学报
Acta Pharmaceutica Sinica
; (12): 1246-1252, 2021.
Article
in Zh
| WPRIM
| ID: wpr-887094
Responsible library:
WPRO
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease with angiogenesis, inflammatory factor infiltration and joint destruction as the main pathological features. Angiogenesis promotes the development of RA and plays an important role in its pathogenesis. The hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin-2 (Ang-2) signal transduction is a critical pathway to induce synovial angiogenesis. Targeting HIF-VEGF-Ang-2 signal transduction to inhibit synovial angiogenesis is a promising approach for RA treatment. This article reviews the role and mechanism of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in RA, in order to provide a new target and strategy for RA treatment.
Full text:
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Index:
WPRIM
Type of study:
Guideline
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2021
Type:
Article