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Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
Natural Product Sciences ; : 97-102, 2017.
Article in English | WPRIM | ID: wpr-88723
ABSTRACT
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (−)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 - 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with IC₅₀ values ranging from 1.4 to 37.5 µM.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetylcholinesterase / Scopoletin / Cholinesterase Inhibitors / Chromones / Coumarins / Angelica Language: English Journal: Natural Product Sciences Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Acetylcholinesterase / Scopoletin / Cholinesterase Inhibitors / Chromones / Coumarins / Angelica Language: English Journal: Natural Product Sciences Year: 2017 Type: Article