Association between lung compliance phenotypes and mortality in COVID-19 patients with acute respiratory distress syndrome
Annals of the Academy of Medicine, Singapore
;
: 686-694, 2021.
Article
in English
| WPRIM
| ID: wpr-887558
ABSTRACT
INTRODUCTION@#Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with a high mortality rate, though outcomes of the different lung compliance phenotypes are unclear. We aimed to measure lung compliance and examine other factors associated with mortality in COVID-19 patients with ARDS.@*METHODS@#Adult patients with COVID-19 ARDS who required invasive mechanical ventilation at 8 hospitals in Singapore were prospectively enrolled. Factors associated with both mortality and differences between high (<40mL/cm H@*RESULTS@#A total of 102 patients with COVID-19 who required invasive mechanical ventilation were analysed; 15 (14.7%) did not survive. Non-survivors were older (median 70 years, interquartile range [IQR] 67-75 versus median 61 years, IQR 52-66; @*CONCLUSION@#COVID-19 ARDS patients with higher compliance on the day of intubation and a longitudinal decrease over time had a higher risk of death.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Respiratory Distress Syndrome, Newborn
/
Lung Compliance
/
SARS-CoV-2
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2021
Type:
Article
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