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Research progress of eicosanoid metabolomics in cardiovascular diseases / 生理学报
Acta Physiologica Sinica ; (6): 606-616, 2021.
Article in Chinese | WPRIM | ID: wpr-887696
ABSTRACT
Eicosanoids are oxidized derivatives of 20-carbon polyunsaturated fatty acids (PUFAs). In recent years, the role and mechanism of eicosanoids in cardiovascular diseases have attracted extensive attention. Substrate PUFAs including arachidonic acid are metabolized by cyclooxygenase, lipoxygenase, cytochrome P450 oxidase enzymes, or non-enzymatic auto-oxidation. Eicosanoid metabolomics is an effective approach to study the complex metabolic network of eicosanoids. In this review, we discussed the biosynthesis and functional activities of eicosanoids, the strategies of eicosanoid metabolomics, and applications and research progress of eicosanoid metabolomics in cardiovascular diseases, which might offer new insights and strategies for the treatment of cardiovascular diseases.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Eicosanoids / Arachidonic Acid / Cytochrome P-450 Enzyme System / Metabolomics Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Eicosanoids / Arachidonic Acid / Cytochrome P-450 Enzyme System / Metabolomics Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article