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Evaluation of Multidrug Resistant Loop-mediated Isothermal Amplification Assay for Detecting the Drug Resistance of / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 616-622, 2021.
Article in English | WPRIM | ID: wpr-887737
ABSTRACT
Objective@#To evaluate multidrug resistant loop-mediated isothermal amplification (MDR-LAMP) assay for the early diagnosis of multidrug-resistant tuberculosis and to compare the mutation patterns associated with the @*Methods@#MDR-LAMP assay was evaluated using 100 @*Results@#The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MDR-LAMP were 85.5%, 93.6%, 96.7%, and 74.4% for the detection of resistance to isoniazid and rifampicin, respectively, and 80.5%, 92.3%, 98.6%, and 41.4% for the detection of @*Conclusion@#MDR-LAMP is a rapid and accessible assay for the laboratory identification of rifampicin and isoniazid resistance of
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidoreductases / Phenotype / Rifampin / Bacterial Proteins / DNA-Directed RNA Polymerases / DNA, Bacterial / Catalase / Nucleic Acid Amplification Techniques / Molecular Diagnostic Techniques / Drug Resistance, Multiple, Bacterial Type of study: Diagnostic study / Screening study Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oxidoreductases / Phenotype / Rifampin / Bacterial Proteins / DNA-Directed RNA Polymerases / DNA, Bacterial / Catalase / Nucleic Acid Amplification Techniques / Molecular Diagnostic Techniques / Drug Resistance, Multiple, Bacterial Type of study: Diagnostic study / Screening study Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article