Evaluation of Multidrug Resistant Loop-mediated Isothermal Amplification Assay for Detecting the Drug Resistance of / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 616-622, 2021.
Article
in English
| WPRIM
| ID: wpr-887737
ABSTRACT
Objective@#To evaluate multidrug resistant loop-mediated isothermal amplification (MDR-LAMP) assay for the early diagnosis of multidrug-resistant tuberculosis and to compare the mutation patterns associated with the @*Methods@#MDR-LAMP assay was evaluated using 100 @*Results@#The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MDR-LAMP were 85.5%, 93.6%, 96.7%, and 74.4% for the detection of resistance to isoniazid and rifampicin, respectively, and 80.5%, 92.3%, 98.6%, and 41.4% for the detection of @*Conclusion@#MDR-LAMP is a rapid and accessible assay for the laboratory identification of rifampicin and isoniazid resistance of
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Phenotype
/
Rifampin
/
Bacterial Proteins
/
DNA-Directed RNA Polymerases
/
DNA, Bacterial
/
Catalase
/
Nucleic Acid Amplification Techniques
/
Molecular Diagnostic Techniques
/
Drug Resistance, Multiple, Bacterial
Type of study:
Diagnostic study
/
Screening study
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2021
Type:
Article
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