Your browser doesn't support javascript.
loading
Expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia and leukoplakia cancerization with spicy diet in Chengdu / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 434-440, 2021.
Article in English | WPRIM | ID: wpr-887755
ABSTRACT
OBJECTIVES@#To investigate the expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia (OLK) and OLK cancerization who have aspicy diet in Chengdu.@*METHODS@#Thirtypatients with OLK andspicy diet and 15 patients with OLK without spicy diet in Chengdu were divided into three groups hyperplastic OLK (OLK-), OLK with mild to moderate dysplasia (OLK+), and severe dysplastic  OLK or oral squamous cell carcinoma (OSCC) transforming from OLK (OLK++/OSCC). The expression of Ki-67, Cyclin D1, P53, and P16 were detected by immunohistochemistry and statistically analyzed.@*RESULTS@#The expression of Ki-67 and P53 in patients with or without spicy diet in the OLK+and OLK++/OSCC groups were stronger than that of the OLK- group (@*CONCLUSIONS@#Spicy diet did not have an influence on the expression of Ki-67, Cyclin D1, P53, and P16 in patients with OLK and OSCC. The expression of Ki-67, Cyclin D1, and P53 increased with the development of OLK, whereas P16 showed opposite expression trend.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukoplakia, Oral / Mouth Neoplasms / Carcinoma, Squamous Cell / Tumor Suppressor Protein p53 / Ki-67 Antigen / Cyclin D1 / Diet / Head and Neck Neoplasms Limits: Humans Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Leukoplakia, Oral / Mouth Neoplasms / Carcinoma, Squamous Cell / Tumor Suppressor Protein p53 / Ki-67 Antigen / Cyclin D1 / Diet / Head and Neck Neoplasms Limits: Humans Language: English Journal: West China Journal of Stomatology Year: 2021 Type: Article