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Application of methyltransferases in microbial synthesis of natural products / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1869-1886, 2021.
Article in Chinese | WPRIM | ID: wpr-887769
Responsible library: WPRO
ABSTRACT
Methyltransferases (MTs) constitute a large group of enzymes that catalyze the transfer of a methyl moiety, most frequently from S-adenosyl-L-methionine, to their substrates. It plays an essential role in regulation of gene expression and synthesis of many natural compounds. Owing to its broad substrate spectrum, MTs make important contributions to diversify the spectrum of products through methylation modifications. Recently, great progress has been made in application of MTs for the biosynthesis of various natural products including phenylpropane compounds, fragrances, hormones and antibiotics, which is summarized in this review. Moreover, we highlighted the strategies of using MTs for efficient production and for expanding the diversity of these methylated natural products, and discussed the current challenges and future prospects in this area.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Products / Methylation / Methyltransferases Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Products / Methylation / Methyltransferases Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2021 Type: Article